2. Natural Products
  3. Alkaloids
  4. Pyrrole Alkaloids

Pyrrole Alkaloids

Pyrrole Alkaloids (240):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2309
    Kainic acid 487-79-6 99.96%
    Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures.
    Kainic acid
  • HY-N0750
    Monocrotaline 315-22-0 99.98%
    Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].
    Monocrotaline
  • HY-14944
    Homoharringtonine 26833-87-4 99.96%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine
  • HY-N0862
    Harringtonine 26833-85-2 99.93%
    Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 μM.
    Harringtonine
  • HY-N0288
    Lycorine 476-28-8 99.87%
    Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription. Lycorine is also a melanoma vasculogenic inhibitor. Lycorine can be used for the study of prostate cancer and metabolic diseases.
    Lycorine
  • HY-W002112
    (±)-Nornicotine 5746-86-1
    (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health.
    (±)-Nornicotine
  • HY-N10574A
    Queuine dihydrochloride 86496-18-6
    Queuine dihydrochloride is a super-modified nucleobase, modified to queuosine dihydrochloride. Queuine dihydrochloride is an important micronutrient that can be used in the study of human intestinal microbial-related diseases.
    Queuine dihydrochloride
  • HY-W106456
    3-Methoxy-9H-Carbazole 18992-85-3 99.64%
    3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole inhibits cancer cell proliferation and induces apoptosis.
    3-Methoxy-9H-Carbazole
  • HY-P1902A
    Cardiotoxin Analog (CTX) IV (6-12) (TFA) 2918768-05-3 99.81%
    Cardiotoxin Analog (CTX) IV (6-12) (TFA) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin.
    Cardiotoxin Analog (CTX) IV (6-12) (TFA)
  • HY-111914A
    Ferroheme 14875-96-8 99.70%
    Ferroheme is a complex of ferrous ions and porphyrins, which exists in tissues in free form and as a prosthetic group of many heme proteins. In addition, ferroheme is also an isosteric inhibitor of fatty acid binding to rat liver fatty acid binding protein.
    Ferroheme
  • HY-W007324
    Maleimide 541-59-3 99.90%
    Maleimide can be used for production of antibody-drug conjugate (ADC) which is used in cancer research. Maleimide also be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes.
    Maleimide
  • HY-N0095
    (S)-10-Hydroxycamptothecin 19685-09-7 99.38%
    (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.
    (S)-10-Hydroxycamptothecin
  • HY-N0298
    Stachydrine 471-87-4 ≥98.0%
    Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
    Stachydrine
  • HY-N0289
    Lycorine hydrochloride 2188-68-3 99.89%
    Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM).
    Lycorine hydrochloride
  • HY-40135
    L-Hydroxyproline 51-35-4 ≥99.0%
    L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
    L-Hydroxyproline
  • HY-N6722
    Swainsonine 72741-87-8 ≥99.0%
    Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.
    Swainsonine
  • HY-N0638
    Dendrobine 2115-91-5 99.92%
    Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively.
    Dendrobine
  • HY-129071
    Vindesine sulfate 59917-39-4 99.91%
    Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 µM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo.
    Vindesine sulfate
  • HY-N6771
    Cyclopiazonic acid 18172-33-3 99.69%
    Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B[1][4][5].
    Cyclopiazonic acid
  • HY-135005
    Biliverdin hydrochloride 856699-18-8 99.3%
    Biliverdin hydrochloride is a tetrapyrrolic, water-soluble compound formed by the breakdown of heme. Biliverdin hydrochloride can upregulate the activity of biliverdin reductase which is an enzyme that is a regulator of the innate immune system.
    Biliverdin hydrochloride